This paper presents an investigation of supportive design features for users from different cultural origins in global e-commerce sites applying the principles of human computer interaction to web interface design. This investigation was necessitated from a need to establish an understanding of the barriers in the implementation of e-business on a global level. The paper begins with an overview of current business-to-user (B2C) e-commerce implementation on the web, and then describes cultural issues in the global e-commerce.