The P2X
7 plasma membrane receptor is an intriguing molecule that is endowed with the ability to kill cells, as well as to activate
many responses and even stimulate proliferation. Here, the authors give an overview on the multiplicity and complexity of
P2X
7-mediated responses, discussing recent information on this receptor. Particular attention has been paid to early and late
signs of apoptosis and necrosis linked to activation of the receptor and to the emerging field of P2X
7 function in carcinogenesis.
Key words cell death - inflammation - P2X7
- proliferation