Welcome!
To use the personalized features of this site, please log in or register.
If you have forgotten your username or password, we can help.
My Menu
Saved Items

Multi-objective Optimisation of Cancer Chemotherapy Using Evolutionary Algorithms

Andrei PetrovskiContact Information and John McCallContact Information

(5)  School of Computer and Mathematical Sciences, The Robert Gordon University, St. Andrew Street, AB25 1HG ABERDEEN, UK
Abstract
The main objectives of cancer treatment in general, and of cancer chemotherapy in particular, are to eradicate the tumour and to prolong the patient survival time. Traditionally, treatments are optimised with only one objective in mind. As a result of this, a particular patient may be treated in the wrong way if the decision about the most appropriate treatment objective was inadequate. To partially alleviate this problem, we show in this paper how the multi-objective approach to chemotherapy optimisation can be used. This approach provides the oncologist with versatile treatment strategies that can be applied in ambiguous cases. However, the conflicting nature of treatment objectives and the non-linearity of some of the constraints imposed on treatment schedules make it difficult to utilise traditional methods of multi-objective optimisation. Evolutionary Algorithms (EA), on the other hand, are often seen as the most suitable method for tackling the problems exhibiting such characteristics. Our present study proves this to be true and shows that EA are capable of finding solutions undetectable by other optimisation techniques.

Contact Information Andrei Petrovski
Email: ap@scms.rgu.ac.uk

Contact Information John McCall
Email: jm@scms.rgu.ac.uk
Fulltext Preview (Small, Large)
Image of the first page of the fulltext

References secured to subscribers.



Export this chapter
Export this chapter as RIS | Text
 
Remote Address: 38.107.191.109 • Server: mpweb19
HTTP User Agent: CCBot/1.0 (+http://www.commoncrawl.org/bot.html)