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Book Chapter
GPU-ClustalW: Using Graphics Hardware to Accelerate Multiple Sequence Alignment
Book Series
Lecture Notes in Computer Science
Publisher
Springer Berlin / Heidelberg
ISSN
0302-9743 (Print) 1611-3349 (Online)
Volume
Volume 4297/2006
Book
High Performance Computing - HiPC 2006
DOI
10.1007/11945918
Copyright
2006
ISBN
978-3-540-68039-0
Category
Session VI – Applications
DOI
10.1007/11945918_37
Pages
363-374
Subject Collection
Computer Science
SpringerLink Date
Monday, December 18, 2006
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Session VI – Applications
GPU-ClustalW: Using Graphics Hardware to Accelerate Multiple Sequence Alignment
Weiguo Liu
1
, Bertil Schmidt
1
, Gerrit Voss
1
and Wolfgang Müller-Wittig
1
(1)
School of Computer Engineering, Nanyang Technological University, Centre for Advanced Media Technology,
Abstract
Molecular Biologists frequently compute multiple sequence alignments (MSAs) to identify similar regions in protein families. However, aligning hundreds of sequences by popular MSA tools such as ClustalW requires several hours on sequential computers. Due to the rapid growth of biological sequence databases biologists have to compute MSAs in a far shorter time. In this paper we present a new approach to reduce this runtime using graphics processing units (GPUs). To derive an efficient mapping onto this type of architecture, we have reformulated the computationally most expensive part of ClustalW in terms of computer graphics primitives. This results in a high-speed implementation with significant runtime savings on a commodity graphics card.
Weiguo
Liu
Email:
liuweiguo@ntu.edu.sg
Bertil
Schmidt
Email:
asbschmidt@ntu.edu.sg
Gerrit
Voss
Email:
asgerrit@ntu.edu.sg
Wolfgang
Müller-Wittig
Email:
askwmwittig@ntu.edu.sg
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