The diagnosis of optic nerve disease is usually made by clinical history and ophthalmoscopic features. Fluoresce in angiography (FA) and indocyanine green videoangiography (ICGV) findings are not pathognomonic for any optic nerve condition. However, there are some instances in which FA can be helpful in making a diagnosis. Furthermore, in some cases, FA may shed light on the pathophysiology of an unknown disease. Indocyanine green videoangiography may be useful in confirming the diagnosis of choroidal hemangioma, and defining occult choroidal neovascularization and chorioretinal inflammatory diseases. Generally speaking, ICGV is not very helpful in the evaluation and diagnosis of optic nerve diseases.