| 1. |
It has been shown that 3,3-dimethylcysteine is readily acylated by means of acid anhydrides and acid chlorides and that it then forms only N-acyl derivatives.
|
| 2. |
3,3-Dimethylcysteine is readily alkylated in aqueous alkaline solution, particularly by halogen-substituted acids, with formation of onlyS-alkyl derivatives. With acid chlorides of -halo carboxylic acids, 3,3-dimethylcysteine forms derivatives of hexahydro-1,4-thiazepin-5-one.
|
| 3. |
It has been shown that the products of theS-alkylation of 3,3-dimethylcysteine with -bromo carboxylic acids are readily converted into derivatives of 3-thiamorpholinone, which is an unusual case of the spontaneous acylation of an amino group by a carboxylic acid.
|