A patient with hepatitis after 2 exposures of Halothane anesthesia developed fever, jaundice, hematemesis, hypoprothrombinemia and hemolysis. Further progression of disease eventuated in a phase of bone marrow failure, a rare complication of hepatitis. A perusal of the literature on this subject implicates the hepatitis virus, autoantibodies and/or the injured liver cell itself in the causation of this process. The case discussed represented the noninfectious category, and involved only the erythroid elements. A spontaneous remission occurred.