The effect of fenarimol, a pyrimidine-containing cytochrome P-450 inhibitor, was tested in vitro on brain-ring gland complexes of
Calliphora vicina (Dipt., Calliphoridae), and on microsomes prepared from the fat body of 0-h wandering stage larvae of
Neobellieria bullata (Dipt., Sacrophagidae). Fenarimol had no influence on the formation of ecdysone, but it was an effective inhibitor of cytochrome P-450-dependent ecdysone 20-monooxygenase.
Key words
Calliphora vicina
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Neobellieria bullata
- fenarimol - synthesis of 20-hydroxy ecdysone - cytochrome P-450 inhibitor - microsomal ecdysone 20-monooxygenase