Approximately 18.2 million Americans had diabetes in 2002 (1). An estimated 70% of type 2 diabetes risk in the United States is attributable to overweight and obesity, with each kilogram of weight gain over 10 yr increasing risk by 4.5% (2). Modest weight loss, often achievable by a combination of reduced caloric intake and increased physical activity, lowers the risk of diabetes and insulin resistance and improves measures of glycemia and dyslipidemia in those with diabetes (3–8).