Hydrallazine (2.5 mg/kg), obsidan (10 mg/kg, and promethazine (10 mg/kg) increased the NAD+NADH content in the liver and brain of intact rats without affecting their relative proportions. These drugs, in the same doses, especially if administered together, raised the NAD+NADH level if depressed by hypoxia and increased the NAD/NADH ratio. It is concluded that the antihypoxic action of hydrallazine, obsidan, and promethazine is perhaps connectd with an increase in the total nicotinamide-adenine dinucleotide content and a relative increase in the content of its oxidized form.
Key Words hydrallazine - obsidan - promethazine - hypoxia - nicotine-adenine dinucleotide
Laboratory of Biochemical Pharmacology, Department of Regulation of Metabolism, Academy of Sciences of the Belorussian SSR, Grodno. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Zakusov.) Translated from Byulleten'' Éksperimental''noi Biologii i Meditsiny, Vol. 86, No. 8, pp. 190–192, August, 1978.