Three investigations were made into the pharmacokinetics of propranolol when added to the existing phenothiazine regime of patients with schizophrenia.
The plasma level was found to depart from a linear relation with dose range 80–1500 mg daily. The peak-to-trough half time was found to increase with increasing dose, and the half life of propranolol was also found to be dose-dependent.
Key words Propranolol - Phenothiazines - Schizophrenia - Plasma level - Half life