The glaucoma drainage devices (GDD) are increasingly popular as the primary procedure over trabeculectomy and cyclo-destructive in the management of refractory glaucoma. Interest in this field is warranted because studies have found significant rates of desirable intraocular pressure (IOP) control as well as maintenance of visual acuity in these difficult cases. GDD have evolved from the first crude attempt, in 1907, using horsehair to drain aqueous from the anterior chamber into the subtenon/conjunctival space at the limbus(1). Since then, various materials, such as silk, gold, platinum, tantalum, glass rod, and polythene tube have been used near the limbus and have failed because of conjunctival erosion, implant migration, extrusion as well as scarring. To overcome these problems, current implants were based on the molteno implant, which has a long tube attached to an explant placed 9–10 mm posterior to the limbus. Current GDD are made from various biomaterials, such as acrylic, silicone, and polypropylene, however, their influence on efficacy and safety has not yet been determined.