The effect of diphenylhydantoin (Dilantin) on the myocardial uptake of
201Tl-chloride was studied in rats. Prior administration of Dilantin caused a significant (38.8) decrease in
201Tl uptake compared with the control group. No significant change in heart to blood or heart to muscle ratios was observed. Administration of Dilantin after
201Tl-chloride did not affect the myocardial concentration of the radionuclide.
This research was supported under Contract No. DE-AC02-76CH 00016 with the U.S. Department of Energy.