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The effect of diphenylhydantoin (Dilantin) on thallium-201 chloride uptake

E. R. Schachner, Z. H. Oster, N. R. Cicale, D. F. Sacker, P. Som, H. L. Atkins and A. B. Brill

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Abstract

The effect of diphenylhydantoin (Dilantin) on the myocardial uptake of 201Tl-chloride was studied in rats. Prior administration of Dilantin caused a significant (38.8) decrease in 201Tl uptake compared with the control group. No significant change in heart to blood or heart to muscle ratios was observed. Administration of Dilantin after 201Tl-chloride did not affect the myocardial concentration of the radionuclide.
This research was supported under Contract No. DE-AC02-76CH 00016 with the U.S. Department of Energy.

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