The absorption of paracetamol from syrup, tablet and two different suppository bases was compared in six adult volunteers using urinary excretion measurements. The total amount of paracetamol and its metabolites excreted and the peak excretion rates were lower from the suppository bases than from the oral dosage forms. Absorption was a little better from a polyethylene glycol suppository base than from a triglyceride base. The antipyretic efficacy of a paracetamol syrup and suppository at a dose of 10 mg/kg was compared in 30 children between the age of 4 months and 12 years, who had infections and a rectal temperature above 38.5°C. Both dosage forms produced a significant decrease in temperature, the greatest fall being about 2 hours earlier with the oral dosage form. The syrup also seemed to be significantly (p<0.05) more="" effective="" (maximum="" fall="" of="" temperature="" 1.58°c)="" in="" reducing="" fever="" than="" the="" suppository,="" which="" produced="" its="" greatest="" fall="" of="" temperature="" (1.24°c)="" six="" hours="" after="" insertion="" of="" the="" suppository.="" from="" the="" practical="" point="" of="" view="" both="" forms="" can="" be="" regarded="" as="" safe="" and="" effective="">