The effects of colchicine, cytochalasin-B and papaverine on wound healing in
Xenopus early embryos have been studied. Colchicine does not prevent wound healing, whereas cytochalasin-B does. Papaverine, under conditions which prevent the completion of neurulation, does not prevent wound healing. A model is given which might explain these observations.
Acknowledgments. We wish to thank Drs M.A. England and J. Wakely, whose friendly discussions first precipitated the idea for these experiments, Dr A.R. Cossins who read the manuscript, Mr F. Schaefer who prepared the semi-thin sections and Mrs J. Clumpus for technical assistance.