The concepts of the information theory can be fruitfully used in nanochemistry. An asymptoticformula is presented for the number of different nanosystems of the same chemical composition. An estimateis given for the maximum value of the specific information capacity. A special attention is paid to the theoret-ical foundations of chemical-information synthesis. The problem of chemical replication of polyatomic systems is analyzed in the adiabatic approximation. The information aspect of operation of a configurationmachine is considered.