Latino men who have sex with other men are disproportionately affected by AIDS/HIV. We describe sociodemographic and psychosocial characteristics of a probability sample of 744 unmarried Latino men, comparing men reporting at least one sexual encounter with another man (MSM; 5.5% of sample) with men reporting sex exclusively with women (MSW) or reporting they were not sexually active (NSA). MSM were significantly older, more acculturated, and more educated than others. MSM were more comfortable with sexuality and reported over twice as many sexual partners in the previous year as MSW. MSM always used condoms with 83% of their multiple partners, compared to 50% of MSW. Homophobia and sexual discomfort among MSM may decrease self-efficacy to use condoms.