Volume 51, Number 7, 1111-1114, DOI: 10.1007/s00125-008-1027-7

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European Association for the Study of Diabetes

The proposed terminology ‘A1c-derived average glucose’ is inherently imprecise and should not be adopted

Z. T. Bloomgarden, S. E. Inzucchi, E. Karnieli and D. Le Roith

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Abstract

The proposed use of a more precise standard for glycated (A1c) and non-glycated haemoglobin would lead to an A1c value, when expressed as a percentage, that is lower than that currently in use. One approach advocated to address the potential confusion that would ensue is to replace ‘HbA1c’ with a new term, ‘A1c-derived average glucose.’ We review evidence from several sources suggesting that A1c is, in fact, inherently imprecise as a measure of average glucose, so that the proposed terminology should not be adopted.

Keyword  Glycated haemoglobin

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