Essentials in Ophthalmology, 2008, 185-199, DOI: 10.1007/978-3-540-33681-5_10

Chronic Blepharitis: Diagnosis, Pathogenesis, and New Treatment Options

Claudia Auw-Haedrich and Thomas Reinhard

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Abstract

■ Chronic blepharitis can cause severe corneal changes, but is surprisingly often not diagnosed
■ Pathogenesis often includes skin diseases, but also bacterial involvement, meibomian gland dysfunction with altered meibomian gland lipids, hormonal imbalance
■ Important sequelae of chronic blepharitis are dry eye syndrome, corneal involvement like keratitis, phlyctenules, pannus, vascularization, corneal ulcers, and lid changes like trichiasis and madarosis
■ The treatment includes mechanical measures, preservative-free artificial tears, steroids, antibiotics, immunomodulatory eye drops (e.g., steroids, cyclosporin) or ointment (e.g., FK506, Pimecrolimus), and occasionally surgical treatment

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