Pulmonary infections are the leading cause of morbidity and mortality in patients with cystic fibrosis. Empiric broad-spectrum antibiotics are often used for prolonged periods and repeatedly for exacerbation of bronchiectasis. Hence, as a consequence this select group of patients has the highest incidence of multi-resistant bacteria causing respiratory colonization or infection second to none. It is estimated that 25–45% of adults with cystic fibrosis are chronically infected with multi-resistant bacteria in their airways.¹