In a large kindred in which the gene for central core disease is segregating, we have demonstrated linkage between the disorder and a marker on chromosome 19q. Marker
D19S9 (p1J2) was linked to central core disease with a lod score of 6.4 at
= 0.03 (support interval 0.01–0.14) thus localizing the gene for this disorder in or very close to 19q12–q13.2.