Quality of life is a multidimensional, subjective idea that defies exact definition. In androgen excess, and even more so in the polycystic ovary syndrome (PCOS), changes in outer appearance, menstrual disturbances, and infertility result in psychological distress, reduced quality of life, and a less satisfying sex life. Although obesity and hirsutism are major determinants of the physical component of quality of life, its psychological aspect appears to be inherent and specific for PCOS. Confirmation of the diagnosis and provision of detailed information to affected women, together with the availability of interdisciplinary treatment, including metformin or thiazolidinediones, have been shown to have positive psychological effects.