The ecosystem approach to environmental management inter-relates social, economic and environmental factors. Its incorporation into the Great Lakes Water Quality Agreement of 1978 changed the focus of the Agreement from water in a political context to politics in an ecosystem context. Because ecosystems are open and dependent on Biospheric processes for their continued operation, the Biosphere (global ecosystem) emerges as a globally integrating factor in ecosystem management. Influences leading to development of the ecosystem approach in the Great Lakes Basin included: a politically shared resource in jeopardy, pollution, a common drinking water source, common enemies, advances in ecosystem theory, citizen groups, international political institutions, common economic and cultural ties, and a sense of crisis. A rationale is presented for viewing nations as politically defined ecosystems.