Experiments on fibroblast-like Chinese hamster cells showed that agents inducing c-mitosis (colchicine, colcemid, low temperature) give rise to two distinct effects: stathmokinetic and radiomimetic. Toward the time of reversibility of the first of these effects, the second becomes clearly manifested as bridge formation. The appearance of this pathological form is evidently due to disturbance of cell nucleoprotein metabolism during c-mitosis.
Key Words pathology of mitosis - stathmokinetic effect - radiomimetic effect - chromosome bridges
Institute of Human Morphology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten'' Éksperimental''noi Biologii i Meditsiny, Vol. 87, No. 6, pp. 587–589, June, 1979.