By an iteration method, the influence of oil film inertia on piston skirt lubrication in a high speed engine is investigated. By alternately solving the Navier-Stocks equations and the Reynolds equation, the new iteration method can trace the variations of velocity field and pressure field with time. Based on this, the mixed-lubrication model suitable for the piston skirt of high engines is proposed. By introducing the inertia coefficient, the new lubrication model includes the inertia term in oil film. The model can be also used to solve for the lubrication performances of a piston skirt in low or medium speed engines and for lubrication problem in general excluding the inertia term of oil film , when the inertia coefficient is put equal to zero. The calculation results show that the influence of oil film inertia on the friction force increases with the ratio of the piston skirt’s length to its diameter, the inertia coefficient and the eccentricities of the lower and the upper piston skirt, with other conditions kept constant, while die influence of it on the load capacity of oil film is small.