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Pooling Evidence to Identify Cell Cycle–Regulated Genes
| Book Series | Lecture Notes in Computer Science |
| Publisher | Springer Berlin / Heidelberg |
| ISSN | 0302-9743 (Print) 1611-3349 (Online) |
| Volume | Volume 3992/2006 |
| Book | Computational Science – ICCS 2006 |
| DOI | 10.1007/11758525 |
| Copyright | 2006 |
| ISBN | 978-3-540-34381-3 |
| Category | Second International Workshop on Bioinformatics Research and Applications (IWBRA06) |
| DOI | 10.1007/11758525_94 |
| Pages | 694-701 |
| Subject Collection | Computer Science |
| SpringerLink Date | Friday, May 12, 2006 |
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Second International Workshop on Bioinformatics Research and Applications (IWBRA06)
Pooling Evidence to Identify Cell Cycle–Regulated Genes
Gaolin Zheng1 , Tom Milledge1 , E. Olusegun George2 and Giri Narasimhan1 
| (1) |
Bioinformatics Research Group (BioRG), School of Computer Science, Florida International University, Miami, Florida, 33199, USA |
| (2) |
Department of Mathematical Sciences, University of Memphis, Memphis, TN 38152, USA |
Abstract
Most of the biological studies have embraced statistical approaches to make inferences. It is common to have several independent
experiments to test the same null hypothesis. The goal of research on pooling evidence is to combine the results of these
tests to ask if there is evidence from the collection of studies to reject the null hypothesis. In this study, we evaluated
four different pooling techniques (Fisher, Logit, Stouffer and Liptak) to combine the evidence from independent microarray
experiments in order to identify cell cycle-regulated genes. We were able to identify a better set of cell cycle-regulated
genes using the pooling techniques based on our benchmark study on budding yeast (Saccharomyces cerevisiae). Our gene ontology study on time series data of both the budding yeast and the fission yeast (Schizosaccharomyces pombe) showed that the GO terms that are related to cell cycle are significantly enriched in the cell cycle-regulated genes identified
using pooling techniques.
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