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The quinolone, flumequine, has no effect on theophylline pharmacokinetics
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Short CommunicationsThe quinolone, flumequine, has no effect on theophylline pharmacokinetics B. Lacarelle1
 , O. Blin1, C. Audebert1, P. Auquier1, H. Karsenty2, F. Horriere2 and A. Durand1 | (1) | Centre de Pharmacologie Clinique et d'Evaluations Thérapeutiques, CHU Timone Adultes, Marseille, France |
| (2) | Recherche et Développement, 3 M Santé, Pithiviers, France |
| (3) | Centre de Pharmacologie Clinique et d'Evaluations Thérapeutiques, CHU Timone Adultes, Bd. Jean Moulin, F-13 385 Marseille Cedex 5, France |
Received: 20 September 1993 Accepted: 17 February 1994 Abstract The kinetics of a single i. v. dose of theophylline given either alone or with flumequine was studied in eight healthy volunteers. No statistically significant differences were observed in the pharmacokinetic parameters of theophylline (volume of distribution, elimination half-life, AUC, plasma clearance) following the two treatments. Pretreatment for 5 days with oral flumequine (400 mg, three times daily) had no significant effect on the disposition of a single i. v. dose of theophylline in healthy volunteers. Key words Theophylline - flumequine - drug interaction - pharmacokinetics
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