A twisted-mode-cavity laser was established by using a piece of c-cut Nd:GdVO₄ crystal as the lasers active material. Output spectra were scanned by a scanning Fabry–Perot interferometer, which demonstrated that the single-longitudinal-mode laser operation was realized in the twisted-mode-cavity laser configuration. A maximum single-longitudinal-mode laser output power of 2.1 W was obtained when the pump power was 11.5 W. The pump slope efficiency was about 20.0%. A passively Q-switched single-longitudinal-mode laser was also achieved in a twisted-mode cavity by inserting a piece of Cr⁴⁺:YAG as an intracavity saturable absorber. The Q-switched single-longitudinal-mode laser pulse duration was measured to be 100 ns and the single-pulse energy was about 40.0 J.