Healthy male subjects were given orally a single dose of 5 mg canrenone per kg body weight. Canrenone caused a significant decrease in plasma testosterone concentration already 3 hrs after administration of the drug. Suppression of plasma testosterone concentration by 50 to 60 per cent persisted over 9 hrs.
It is concluded that suppression of testosterone production is an important factor in the antiandrogenic activity of spirolactones in man.
Key words Spirolactones - Canrenone - Antiandrogenic Effect - Plasma Testosterone