A 42-year-old man presented with a cotton-wool spot. The diagnosis of brucellosis was made by tube agglutination test and
blood culture. Clinical findings and the cotton-wool spot disappeared within 3 weeks after antibrucellar treatment. The cotton-wool
spot, which was seen in the course of systemic brucellosis, expands the ocular manifestations of brucellosis. Physicians should
keep in mind that cotton-wool spots could be a manifestation of brucellosis in endemic areas.
The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer
or provider of services discussed in this article.