Hepatitis E is an emerging disease in resource-poor regions of the world. It is estimated that about 2 billion people live
in areas endemic for this disease. The inability to reproducibly culture hepatitis E virus makes it impossible to develop
traditional live or inactivated vaccines. However, significant progress has been made in developing and testing recombinant
subunit vaccines based on the viral capsid protein. This review summarizes these efforts.
Keywords Hepatitis - Hepatitis E - HEV - Vaccine