Volume 31, Number 1, 37-43, DOI: 10.1007/BF01876800

A complex mosaic with tdic(13;18) (p11;p11), +13p-, +18p-, r(13)etc. In a male infant
II. Increased dissociation of dicentric chromosome by mitomycin C

Mariko Uehara and Mitsushiro Kida

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Abstract

When cultured lymphocytes of a patient with 45,XY,t(13;18) (p11.1-2;p11.2) were treated with mitomycin C (MMC), dissociations of t(13;18) chromosomes were increased as compared with controls. Furthermore, various other anomalies in volving t(13;18), 13 and 18 chromosomes were observed, which seemed to have resulted from breakage-fusion-bridge (BFB) cycles due to MMC.

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