The use of plant based systems in hazardous waste management or site clean up is growing at a rapid rate. Major hurdles to implementation will be encountered by proponents if essential regulatory policies and regulations are not understood or addressed early in the project development. Understanding the regulatory requirements or issues as they relate to innovative clean up approaches such as phytotechnologies are critical to the successful implementation and long-term monitoring of these technologies. This chapter will address the issues that regulators may have in applying phytotechnologies to site conditions or contaminants, designing phytoremediation projects, monitoring or maintaining the systems for the long-term, establishing performance criteria, and demonstrating achievement of performance goals.