DESIGN: Retrospective cohort trial based on the Cleveland Veterans’ Affairs Medical Center Firm System.

SETTING: General internal medicine teaching clinic in a large university-affiliated Department of Veterans Affairs Medical Center.

PARTICIPANTS: All patients seen in the intervention firm (n=1273) and control firm (n=884) clinics in the 3-month period following the introduction of the guidelines.

INTERVENTIONS: The control firm received guidelines and usual education for the cost-effective outpatient management of hypertension. The intervention firm received guidelines plus intensive guideline-based education and supervision.

MEASUREMENTS AND MAIN RESULTS: The use of guideline medications was greater in the intervention firm as compared with the control. The intervention firm initiated more hydrochlorothiazide (HCTZ), 17.4% (95% confidence interval [CU 14.8, 20.1) of patients versus 11.9% (CI 9.3, 14.8) in the control firm (p=.002). Atenolol was initiated in 7.2% (CI 5.6, 9.0) in intervention firm versus 4.7% (CI 3.2, 6.6) in the control (p=.03). In addition, the use of nonguideline medications was less in the intervention firm. The intervention firm initiated less long-acting nifedipine, 7.8% (CI 6.0, 9.8) versus 10.6% (CI 8.2, 13.5) in the control (p=.04). Blood pressure control demonstrated greater improvement in the intervention firm (p=.02). Use of guidelines was associated with decreased costs for antihypertensive medications in the intervention firm as a whole as compared with the control firm. There was no increased use in other measured resources in the intervention firm including the number of outpatient laboratory services obtained, clinic visits, emergency room visits, or hospitalizations.

CONCLUSIONS: Intensive implementation of guideline-based education and supervision was associated with an increased use of guideline medications, decreased use of costly alternative agents, and no decrement in the measured outcomes of care.