This article estimates the interest rate and exchange rate risk betas of 59 large U.S. commercial banks for the period of 1975–1992, as well as the bank-specific determinants of these betas. The estimation procedure uses a modified seemingly unrelated simultaneous method that recognizes cross-equation dependencies and adjusts for serial correlation and heteroskedasticity. Overall, the exchange rate risk betas are more significant than the interest rate risk betas. More importantly, we find a link between the scale of a bank''s interest rate and currency derivative contracts and the bank''s interest rate and exchange rate risks. Particularly noteworthy is the influence of currency derivatives on exchange rate betas.