Welcome!
To use the personalized features of this site, please log in or register.
If you have forgotten your username or password, we can help.
|
 |
Severe vascular toxicity associated with vinblastine, bleomycin, and cisplatin chemotherapy
| |
|
Original Articles
Vinblastine, Bleomycin, Cisplatin Vascular Toxicity, ChemotherapySevere vascular toxicity associated with vinblastine, bleomycin, and cisplatin chemotherapy Brian L. Samuels1, Nicholas J. Vogelzang1 and B. J. Kennedy2
 | (1) | Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, Ill, USA |
| (2) | Department of Medicine, Section of Medical Oncology, University of Minnesota, Minneapolis, Minn, USA |
Received: 29 May 1986 Accepted: 30 December 1986 Summary Vascular toxicity following the use of vinblastine, bleomycin, and cisplatin (VBP) combination chemotherapy has been described. This report gives details of 5 patients who suffered acute life-threatening vascular events following such a chemotherapy regimen for germ cell tumors. In 3 of the cases no evidence of tumor was found at autopsy. Both an acute and a long-term vascular toxicity were seen. Large artery vascular disease may result from synergistic toxicity of the drugs comprising the regimen. These cases, with an additional 16 collected from the literature, suggest that major vascular disease is a significant side-effect of the VBP regimen. Supported by the Jazz and Blues Fund and by the Deborah Goldfine Reva Smilgoff Memorial Fund. Brian Samuels is the Triangle Industries Cancer Research Fellow
Fulltext Preview (Small, Large)
 References secured to subscribers.
|
|
|
|
|
|