| 1. |
The reactivity of 16 ,17-epithio-ketones in the pregnane series and their 20-carbethoxyhydrazones was studied in the episulfide ring-opening reactions.
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| 2. |
Epithio-ketones are more inert to ring-opening reactions with nucleophilic reagents than the corresponding epoxy-ketones, and tend to eliminate sulfur under the hetero ringopening conditions.
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| 3. |
Substitution of the 20-keto group for the hydrazone fragment does not increase the reactivity of the episulfide ring, but facilitates its desulfurization.
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For communication 100, see [1].
Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 1, pp. 180–185, January, 1979.