During the last decade several palladium-catalyzed reactions have been developed and optimized to a stage that enables application on an industrial scale. The importance of these reactions as novel key steps for fine chemical synthesis is shown. Examples include palladium-catalyzed Heck, Suzuki and Sonogashira coupling reactions, telomerization of 1,3-butadiene with nucleophiles, and carbonylation of aromatic and benzylic halides.