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Original Article

Pediatric eosinophilic esophagitis: radiologic findings with pathologic correlation

Larry A. Binkovitz1, 4 Contact Information, Emily A. Lorenz1, Carlo Di Lorenzo2 and Samir Kahwash3

(1)  Nationwide Children’s Hospital, Columbus, OH, USA
(2)  Department of Gastroenterology, Nationwide Children’s Hospital, Columbus, OH, USA
(3)  Department of Pathology, Nationwide Children’s Hospital, Columbus, OH, USA
(4)  Present address: Mayo Clinic, Division of Pediatric Radiology, E-2, 200 First Ave. SW, Rochester, MN 55901, USA

Received: 2 July 2009  Revised: 13 October 2009  Accepted: 19 November 2009  Published online: 18 December 2009

Abstract
Background   
Eosinophilic esophagitis is increasingly recognized as a cause of dysphagia or food impaction in pediatric patients. It has a high male predominance and is often associated with a history of allergy or asthma.
Objective   
To correlate fluoroscopic findings in eosinophilic esophagitis with the endoscopic and histologic findings.
Materials and methods   
We retrospectively reviewed the upper gastrointestinal (UGI) findings of eosinophilic esophagitis and correlated them with the clinical, endoscopic and histologic findings in a series of 17 children (12 boys, 5 girls).
Results   
UGI findings were normal in 12 children, including 4 who had a normal UGI exam after endoscopic disimpaction for an obstructing food bolus. Five children had strictures identified on UGI: one was demonstrated with endoscopy. This suggests that the impactions and strictures were due to an esophageal dysmotility rather than a fixed anatomic abnormality.
Conclusion   
Because the UGI findings are frequently normal in eosinophilic esophagitis, radiologists need to have a high index of suspicion for this disease. In children with a strong clinical history, especially impaction in the absence of an esophageal stricture, endoscopy and biopsy are indicated for further evaluation.

Keywords  Eosinophilic - Esophagus - Fluoroscopy - Dysphagia


Contact Information Larry A. Binkovitz
Email: binkovitz@yahoo.com
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