Volume 53, Number 1, 7-12, DOI: 10.1007/BF01352007

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International Osteoporosis Foundation

Regional and total body bone mineral content, bone mineral density, and total body tissue composition in children 8–16 years of age

R. A. Faulkner, D. A. Bailey, D. T. Drinkwater, A. A. Wilkinson, C. S. Houston and H. A. McKay

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Abstract

Normative values for total body bone mineral content (TBBM) and total body bone mineral density (TBMD) were derived from measurements on 234 children 8–16 years of age. In addition, bone mineral content (BMC) and bone mineral density (BMD) values for selected regions of interest and soft tissue (bone free lean and fat) for the total body are presented. Bone mineral and soft tissue values were determined by dual energy X-ray absorptiometry (DXA) using a Hologic QDR-2000 in the array mode. Results of a stepwise multiple regression analysis revealed a significant correlation between bone-free lean tissue (BFLT) and BMD (r2 = 0.80) in girls. Adding age to the equation accounted for an additional 2% of the variance (P < 0.05)="" and="" height="" accounted="" for="" another="" 1%="" of="" the="" variance="">P < 0.05).="" body="" weight="" and="" fat="" tissue="" (ft)="" did="" not="" account="" for="" any="" additional="" variance.="" in="" boys="" bflt="" correlated="" significantly="" with="" bmd="">2 = 0.75;P < 0.05);="" none="" of="" the="" other="" predictor="" variables="" accounted="" for="" additional="" variance.="" no="" significant="" differences="" were="" found="" in="" tbbm="" or="" tbmd="" between="" boys="" and="" girls="" at="" any="" age.="" there="" was="" a="" significant="" overall="" gender="" effect="" for="" only="" three="" regions="" of="" interest.="" boys="" had="" greater="" bmc="" in="" the="" head="" region="" and="" had="" greater="" bmd="" in="" the="" upper="" limbs,="" but="" post="" hoc="" analysis="" revealed="" no="" significant="" differences="" for="" any="" specific="" age="" groups.="" girls="" had="" greater="" overall="" bmd="" in="" the="" pelvis,="" but="" this="" difference="" was="" only="" significant="" at="" the="" 15–6-year="" age="" group.="" the="" changes="" in="" bflt="" and="" ft="" over="" the="" age="" ranges="" were="" consistent="" with="" the="" growth="">
The normative values can be applied to the assessment of children and adolescents with health problems that may impact on the skeleton as well as to research studies investigating bone mineral development in children.

Key words  Bone mineralization - Body composition - Children - DXA

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