From December 1996 to March 2004, 27 consecutive patients (both private and public) presented with large uterine fibroid masses to be removed, which subsequently weighed 500 g or more. All were scheduled for a laparoscopic hysterectomy procedure where the uterine vessels are secured laparoscopically using a linear cutter-stapling device. The data from these cases was collected prospectively. Twenty-six of the large uterine fibroid masses were successfully removed by planned laparoscopic hysterectomy without major complication. One case had to be opened because of dense pelvic adhesion, and it was the case with the largest mass in the series (1,280 g). The mean weight of the removed masses was 704.6 g (range: 500–1,280 g). Operating times were long (mean 220 min), but the postoperative stay was short (mean 2.26 days). Laparoscopic hysterectomy a using linear cutter-stapling device to secure the uterine vessel pedicles for large uterine fibroid masses is a useful and effective procedure in most cases with fast patient recovery.