To investigate the changes in the multifocal electroretinography (ERG) after combined intravitreal bevacizumab and photodynamic
therapy (PDT) for polypoidal choroidal vasculopathy (PCV) patients. Thirteen eyes of 13 patients were included in the study.
The latencies and average response densities of all the six ring retinal regions were measured and compared before treatment
and 1, 3, and 6 months after treatment. The latencies of the N1 and P1 waves in all the six rings remained unchanged compared
with pre-treatment. Significant increase of average response densities of both P1 in ring 1 (
P = 0.023) and N1, P1 in ring 2 (
P = 0.028 and 0.046, respectively) were detected at 3 months post-treatment. The increase of P1 amplitude densities in ring
1 (
P = 0.015) and N1, P1 amplitude densities in ring 2 (
P = 0.031 and 0.034, respectively) were also significant at 6 months post-treatment. In conclusion, combined intravitreal bevacizumab
and PDT is associated with an increase of multifocal ERG centrally in PCV patients.
Keywords Polypoidal choroidal vasculopathy - Photodynamic therapy - Bevacizumab - Multifocal electroretinography
The study conformed to the provisions of the Declaration of Helsinki and informed consent was obtained from all the patients.
The authors indicate no conflict of interest. The authors have full access to all the data in the study and take responsibility
for the integrity of the data and the accuracy of the data analysis as well as the decision to submit for publication.