In dogs anæsthetized with morphine-chloralosane, the cerebral ventricles are perfused with artificial solutions. After having been warmed up to body temperature, these solutions are allowed to flow into a lateral ventricle by a needle inserted laterally through the skull, the outflow taking place through a second needle placed suboccipitally in the cisterna. An excess of potassium in the cerebral ventricles increases the vasomotor tonus and the vasomotor responses produced by faradization of the central end of the vagus in the neck and by changing the pressure in the isolated carotid sinuses. An excess of calcium depresses the tonus of the vasomotor center and its reflex responses. An excess of calcium may be neutralized by an excess of potassium. Perfusion with a solution containing no calcium increases the tonus and the responses of the vasomotor center, while the absence of potassium does not seem to have any influence on the vasomotor system. A solution without potassium and calcium produces an increase of the tonus and the responses of the vasomotor center, these effects being due to the absence of calcium.