This paper describes a TLC-densitometric procedure for identification and determination of bisoprolol, labetalol, and propafenone
in pharmaceutical preparations. The compounds were derivatized with dabsyl chloride and chromatographed on silica gel by ascending
development. The separation of the dabsylated drugs was followed by densitometric quantitation. The method was satisfactorily
applied to pharmaceutical preparations. The
RSD of quantitation was between 1.6 and 2.3%.
Key Words Thin-layer chromatography - Densitometry - Bisoprolol, labetalol, and propafenone - Dabsyl derivatives