Comparative toxicity of indomethacin and piroxicam at low multiples of the human therapeutic dose was studied in inbred albino
rats of both sexes. Using the drug-induced model, the two drugs were used to produce gastric ulcers in the rat. Both showed
significant evidence of gastric ulceration measured by the ulcer index. The incidence of ulceration increased with dose for
both drugs. Piroxicam produced a lower incidence of gastric ulcers than equivalent doses of indomethacin.
Key words Piroxicam - Indomethacin - Gastric ulcers - Ulcer Index - Therapeutic doses - Rat