Nitrofurantoin causes damage to DNA of cultured diploid human fibroblasts. As a consequence DNA synthesis is blocked. The damage is removed by the normal enzymatic DNA repair system. Xeroderma pigmentosum fibroblasts which are defective in the excision endonuclease fail to repair nitrofurantoin-caused lesions.
Nitrofurantoin verursacht Schäden an DNA menschlicher diploider Fibroblasten in Kultur. Dadurch wird die DNA-Synthese gestoppt. Die Schäden werden durch das normale enzymatische DNA-Reparatursystem entfernt. Xeroderma-pigmentosum-Fibroblasten, die defekt in der Exzisions-Endonuklease sind, können die Nitrofurantoin-Läsionen nicht reparieren.
Key words Nitrofurantoin mechanism of antibacterial action - Drug side effects - Diploid human fibroblasts - DNA repair - Xeroderma pigmentosum
Schlüsselwörter Mechanismus der antibakteriellen Wirkung - Pharmakologische Nebenwirkungen - Diploide menschliche Fibroblasten - DNA-Reparatur - Xeroderma pigmentosum