Combined electro-acupuncture with general anesthesia in pneumonectomy was studied here. The result showed that general anesthesia complemented with electro-acupuncture at the points of Hegu (LI 4) and Sanyangluo (SJ 8) enabled us to have reduced amount of fentanyl 38~85 μg/h compared with general anesthesia alone in each case. There were no statistical differences in blood pressure and heart rate during the operation in every group, all of the arterial oxygen saturation (SpO₂) were in normal range. It was considered that electro-acupuncture in combination with general anesthesia could reduce the use of dosage of anesthetics and the inhibition of physiological functions. It is a practical anesthetic method acceptible to the thoracic surgeon and patients.