| 1. |
The pK
a
values of 10 phenolic steroids were determined. It is shown that the introduction of a  8(9)-double bond conjugated with the aromatic A ring increases the degree of ionization of the phenolic hydroxyl group.
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| 2. |
It is shown that transition for 17- and 17 -keto-3-hydroxy-1,3,5(10)-estratrienes to the corresponding 3,17 - and 3,17-dihydroxy compounds as well as from the normal series to the D homoanalogs is accompanied by a decrease in acidity, which may be the result of the distance effect from the D ring to the A ring.
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| 3. |
A linear correlation is observed between the chemical oxidation constants (k2) and the dissociation constants (K) of 3,17-dihydroxy-1,3,5(10)-estratrienes, which makes it possible to assume the existence of an interaction between C3 and C17 (C17) by means of distance effects from the A ring to the D ring and from the D ring to the A ring.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 726–728, March, 1972.