We report the case of a patient with amoxicillinclavulanic acid-induced hepatitis with histologic multiple granulomas. This type of lesion broadens the spectrum of liver injury due to this drug combination, mainly represented by a benign cholestatic syndrome. The association of granulomas and eosinophilia favor an immunoallergic mechanism. As penicillin derivatives and amoxicillin alone are known to induce such types of lesions, the amoxicillin component, with or with-out a potentiating effect of clavulanic acid, might have a major role.
Key Words hepatic granuloma - hepatitis - amoxicillin-clavulanic acid