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Immunoreactivity for bcl-2 protein in malignant mesothelioma and non-neoplastic mesothelium

Immunoreactivity for bcl-2 protein in malignant mesothelioma and non-neoplastic mesothelium

JournalVirchows Archiv
PublisherSpringer Berlin / Heidelberg
ISSN0945-6317 (Print) 1432-2307 (Online)
IssueVolume 424, Number 6 / July, 1994
CategoryOriginal Article
DOI10.1007/BF01069743
Pages631-634
Subject CollectionMedicine
SpringerLink DateTuesday, February 22, 2005
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Original Article

Immunoreactivity for bcl-2 protein in malignant mesothelioma and non-neoplastic mesothelium

K. Segers1, M. Ramael1, S. Kumar Singh1, E. Van Marck1   Contact Information, J. Weyler2, J. Van Meerbeeck3 and P. Vermeire3

(1) Department of Pathology, University Hospital of Antwerp, University of Antwerp, Wilrijkstraat 10, B-2650 Edegem, Belgium
(2) Department of Epidemiology and Social Medicine, University of Antwerp, Wilrijk, Belgium
(3) Department of Respiratory Medicine, University Hospital of Antwerp, University of Antwerp, Edegem, Belgium

Received: 1 April 1994  Accepted: 28 April 1994  

Abstract  Immunohistochemical study of bcl-2 protein immunoreactivity in human non-neoplastic mesothelium (44 cases) and in malignant mesothelioma (62 cases) using a murine monoclonal antibody (clone 124) showed cytoplasmic immunoreactivity for bcl-2 protein in five cases of malignant mesothelioma. Non-neoplastic mesothelium was not immunoreactive. Immunoreactivity for bcl-2 protein does not add useful prognostic information in malignant mesothelioma since survival times of bcl-2 positive and bcl-2 negative cases did not differ. Nevertheless, the detection of bcl-2 protein in malignant mesothelioma might be useful for the differentiation from reactive mesothelium.

Key words  Bcl-2 protein - Mesothelioma - Pleura - Immunohistochemistry - Prognosis

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  1. Cappello, Francesco (2001) Poorly differentiated synovial sarcoma: A case report. Pathology & Oncology Research 7(1)
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  2. Kawauchi, Shigeto (1997) Subcellular localization of Bcl-2 protein in synovial sarcoma. Pathology International 47(12)
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  3. Fennell, Dean A (2008) Advances in the systemic therapy of malignant pleural mesothelioma. Nature Clinical Practice Oncology
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  4. Smythe, W. Roy (2002) Current therapy for malignant mesothelioma. Current Oncology Reports 4(4)
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  5. Lee, Amie Y. (2007) Update on the molecular biology of malignant mesothelioma. Cancer
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  6. Higashiyama, Masahiko (1997) bcl-2 oncoprotein in surgically resected nonsmall cell lung cancer: Possibly favorable prognostic factor in association with low incidence of distant metastasis. Journal of Surgical Oncology 64(1)
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  7. Kato, Yasufumi (2006) Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. Modern Pathology
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  8. King, J (2006) Sensitivity and specificity of immunohistochemical antibodies used to distinguish between benign and malignant pleural disease: a systematic review of published reports. Histopathology 49(6)
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  9. O'Kane, Sara (2006) Expression of Bcl-2 Family Members in Malignant Pleural Mesothelioma. Acta Oncologica 1(1)
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  10. Aubry, Marie-Christine (2001) American Journal of Surgical Pathology 25(6)
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